Even Luffy knows he stands no chance vs Big Mom in Big Mom's turf with half a crew and no allies. He said so himself in an earlier chapter, somewhere along the lines I will fight you but not now. Sure he's spouting out he'll fight her here and now but that's only something he'll do if he has no other option in order to protect his nakama. Having Vinsmokes as an ally changes absolutely nothing. You still can't compare Luffy's strength to Big Mom's. AND even if he's able to hold her back for a bit who's taking care of the other 2 commanders? Sanji? Jinbei? Vinsmokes that seemed to be easily handled by Sanji? I don't think so. Vinsmokes are all pure evil except Reiju. I can see Reiju being saved but not the others. I can also see Reiju sacrificing herself while Mugiwaras escape as well. I don't see Luffy having a fight vs Big Mom especially considering this arc will be over in the next 2-3 months.